BDBM14415 2-(azetidin-3-yl)-5-(5-acetyl-2-propoxypyridin-3-yl)-3-propyl-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::5-(5-Acetyl-2-propoxy-3-pyridinyl)-2-(3-azetidinyl)-3-propyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 45

SMILES CCCOc1ncc(cc1-c1nc2c(CCC)n(nc2c(=O)[nH]1)C1CNC1)C(C)=O

InChI Key InChIKey=QYLKBUCWXBJAGB-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14415   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

LigandPNGBDBM14415(2-(azetidin-3-yl)-5-(5-acetyl-2-propoxypyridin-3-y...)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CCC)n(nc2c(=O)[nH]1)C1CNC1)C(C)=O
Show InChI InChI=1S/C21H26N6O3/c1-4-6-16-17-18(26-27(16)14-10-22-11-14)20(29)25-19(24-17)15-8-13(12(3)28)9-23-21(15)30-7-5-2/h8-9,14,22H,4-7,10-11H2,1-3H3,(H,24,25,29)
Affinity DataIC50: 18.2nMAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair