BDBM150357 US10238633, Example 31::US8987249, 31

SMILES CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1F

InChI Key InChIKey=JXOWBXXJEMLQAI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 150357   

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150357(US8987249, 31 | US10238633, Example 31)
Affinity DataIC50: 4.30nMAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150357(US8987249, 31 | US10238633, Example 31)
Affinity DataIC50: 4.30nMT: 2°CAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2015
Entry Details
US Patent

TargetCathepsin K(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150357(US8987249, 31 | US10238633, Example 31)
Affinity DataIC50: 7.30E+3nMAssay Description:To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent