BDBM150667 US10238633, Example 341::US8987249, 341::US9713606, 341

SMILES O=C(NC(Cc1ccc2c3cccc(C(=O)NC4CC4)c3[nH]c(=O)c2c1)C#N)[C@H]1N[C@@H]2CC[C@H]1C2

InChI Key InChIKey=XSGLWSMLJBTVAM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 150667   

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150667(US8987249, 341 | US9713606, 341 | US10238633, Exam...)
Affinity DataIC50: 7.60nMpH: 6.0 T: 2°CAssay Description:Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150667(US8987249, 341 | US9713606, 341 | US10238633, Exam...)
Affinity DataIC50: 7.60nMT: 2°CAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2015
Entry Details
US Patent

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150667(US8987249, 341 | US9713606, 341 | US10238633, Exam...)
Affinity DataIC50: 7.60nMAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent