BDBM15173 5-phenyl-6-{4-[({[4-(1,2,3-thiadiazol-4-yl)phenyl]methyl}amino)methyl]phenyl}pyridine-3-carbonitrile::cyanopyridine 7b

SMILES N#Cc1cnc(-c2ccc(CNCc3ccc(cc3)-c3csnn3)cc2)c(c1)-c1ccccc1

InChI Key InChIKey=FWYIMAUKHHHKGK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15173   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15173(5-phenyl-6-{4-[({[4-(1,2,3-thiadiazol-4-yl)phenyl]...)
Affinity DataIC50:  1.29E+3nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15173(5-phenyl-6-{4-[({[4-(1,2,3-thiadiazol-4-yl)phenyl]...)
Affinity DataIC50: >5.00E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15173(5-phenyl-6-{4-[({[4-(1,2,3-thiadiazol-4-yl)phenyl]...)
Affinity DataIC50:  4.81E+3nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed