BDBM151938 US8987457, 132

SMILES COCCOc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1C1C[C@H](C)[C@@H]([C@H](N)C1)n1ccnn1

InChI Key InChIKey=WYFWPBSKKJQUBK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 151938   

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis

US Patent
LigandPNGBDBM151938(US8987457, 132)
Affinity DataIC50: 0.0400nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM151938(US8987457, 132)
Affinity DataIC50: 1.45nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandPNGBDBM151938(US8987457, 132)
Affinity DataIC50: 1.08nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent