BDBM15345 Asinex compound no. 1::N-(2,4-dichlorophenyl)naphthalene-2-carboxamide

SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1

InChI Key InChIKey=WZYJDNGSKRVUPE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15345   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [H185A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Affinity DataIC50:  80nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed