BDBM155128 US9000184, 2

SMILES CC1=NC2(N=C1N)c1cc(ccc1CCC21CC1)-c1cc(F)cc(c1)C#N

InChI Key InChIKey=MAUWSMJVVWTKNC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 155128   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM155128(US9000184, 2)
Affinity DataIC50:  23nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM155128(US9000184, 2)
Affinity DataIC50:  79nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human beta -Secretase (AA 1-AA 460) was cl...More data for this Ligand-Target Pair
In DepthDetails US Patent