BDBM15518 (3R,4R)-1-(6-(3-(methylsulfonyl)phenyl)pyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)-piperidin-3-amine::(3R,4R)-1-[6-(3-methanesulfonylphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine::Piperidine-Constrained Phenethylamine 42

SMILES CS(=O)(=O)c1cccc(c1)-c1cc(ncn1)N1CC[C@@H]([C@@H](N)C1)c1cc(F)c(F)cc1F

InChI Key InChIKey=GOBIXGZJSMAOFV-QRWLVFNGSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15518   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15518((3R,4R)-1-(6-(3-(methylsulfonyl)phenyl)pyrimidin-4...)
Affinity DataKi:  4nM ΔG°:  -11.3kcal/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15518((3R,4R)-1-(6-(3-(methylsulfonyl)phenyl)pyrimidin-4...)
Affinity DataKi:  4nMAssay Description:Inhibition of dipeptidyl peptidase 4 (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15518((3R,4R)-1-(6-(3-(methylsulfonyl)phenyl)pyrimidin-4...)
Affinity DataKi: >3.00E+4nMAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15518((3R,4R)-1-(6-(3-(methylsulfonyl)phenyl)pyrimidin-4...)
Affinity DataKi: >3.00E+4nMAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed