BDBM160060 US10047092, 1::US9040534, 1

SMILES Fc1ccc(cc1)-c1nnc2C(=O)N(Cc3cccc(c3Cl)C(F)(F)F)CCn12

InChI Key InChIKey=LCNBYJZWIZWCKK-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 160060   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160060(US10047092, 1 | US9040534, 1)
Affinity DataKi:  63.1nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160060(US10047092, 1 | US9040534, 1)
Affinity DataKi:  63.1nMAssay Description:Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160060(US10047092, 1 | US9040534, 1)
Affinity DataIC50: 148nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160060(US10047092, 1 | US9040534, 1)
Affinity DataIC50: 148nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160060(US10047092, 1 | US9040534, 1)
Affinity DataIC50: 2.84E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160060(US10047092, 1 | US9040534, 1)
Affinity DataIC50: 2.84E+4nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent