BDBM16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one

SMILES O=C1c2ccccc2-c2n[nH]c3cccc1c23

InChI Key InChIKey=ACPOUJIDANTYHO-UHFFFAOYSA-N

Data  89 IC50  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 93 hits for monomerid = 16018   

TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataKd:  22nMAssay Description:Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 8/9(Human)
Complutense University of Madrid

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1/2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 68nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2014
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataKd:  84nMAssay Description:Binding affinity to human full-length JNK2 (M1 to Q382 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human JNK3 after 40 mins by [gamma-33ATP] radiometric assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human JNK3 using ATF2 peptide as substrate incubated for 40 mins in presence of gamma-33-P-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 91nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 98nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataKd:  100nMAssay Description:Binding affinity to human full-length JNK1 (M1 to Q384 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human JNK1 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 110nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 150nMpH: 7.0 T: 2°CAssay Description:HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 190nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2014
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 650nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 720nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 880nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 910nMAssay Description:Inhibition of human JNK1-alpha1 using ATF2 peptide as substrate incubated for 40 mins in presence of gamma-33-P-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 957nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2008
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.02E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.05E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.09E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.59E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 1.95E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Displayed 1 to 50 (of 93 total ) | Next | Last >>