BDBM161814 US9051279, 31

SMILES CC(C)N(CCN(C)C)c1ccc2CC(=O)N(C(c3ccc(Cl)cc3)c2c1)c1ccc(cc1)N(C)Cc1ccncc1

InChI Key InChIKey=VVDDORQGXUJPER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 161814   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM161814(US9051279, 31)
Affinity DataIC50: 154nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandPNGBDBM161814(US9051279, 31)
Affinity DataIC50: 1.14E+4nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent