BDBM16312 (4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione::CHEMBL266497::Sorbinil

SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1

InChI Key InChIKey=LXANPKRCLVQAOG-UHFFFAOYSA-N

Data  85 IC50  3 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 85 hits for monomerid = 16312   

LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 17nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 17nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 20nMAssay Description:Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 29nMAssay Description:Inhibition of Sprague-Dawley rat kidney ALR1 using sodium D-glucuronate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member A1(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 67nMAssay Description:In vitro inhibition of rabbit lens aldose reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 70nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 70nMAssay Description:The compound was tested for the inhibition of Aldose reductase in rat lens assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 73nMAssay Description:Concentration required to produce 50% inhibition of aldose reductase enzyme (the literature IC50 value for sorbinil is 0.07 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 140nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against bovine lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 170nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration against aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against aldose reductase in rat lensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against rat lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 230nMAssay Description:Inhibition of aldose reductase from rat lens. Value ranges from 0.07 - 1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductase in rat lensesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 250nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 250nMAssay Description:Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 250nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 280nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 430nMAssay Description:Inhibition of rat lenses ALR2 using DL-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 4 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity towards human placenta aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [L301M](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against human placental aldose reductase (HPAR) with glyceraldehyde as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 550nMAssay Description:Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 620nMAssay Description:Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 650nMAssay Description:Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 650nMAssay Description:Inhibition of ARL2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against human placental aldose reductase in 30 -70% (NH4)2SO4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 750nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 900nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 910nMAssay Description:Inhibition of human recombinant aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 919nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 971nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 990nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against human placenta aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Pig)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of aldose reductase from pig lensesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member A1(Human)
Case Western Reserve University School of Medicine

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldeh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 85 total ) | Next | Last >>

Activity Spreadsheet -- ITC Data from BindingDB

Found 3 hits for monomerid = 16312   

CellAldose reductase (AR)(Human)
Philipps University Marburg

SyringePNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
ITC DataΔG°: -9.05kcal/mole logk: 4.50E+6
T: 24.85°C 
CellAldose Reductase (ALR2) Mutant (L300P)(Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

SyringePNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
ITC DataΔG°: -9.24kcal/mole −TΔS°: 1.91kcal/mole ΔH°: -11.2kcal/mole logk: 6.10E+6
pH: 8.0 T: 24.85°C 
CellAldose reductase (AR)(Human)
Philipps University Marburg

SyringePNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
ITC DataΔG°: -9.05kcal/mole −TΔS°: 3.32kcal/mole ΔH°: -12.4kcal/mole logk: 4.50E+6
pH: 8.0 T: 24.85°C