BDBM163946 US9062078, 77::US9637496, 77::US9695183, 77

SMILES Cn1cc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-c1ccccc1

InChI Key InChIKey=MZAYCAFHEIOHEK-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 163946   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  66nM ΔG°:  -9.10kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  66nM ΔG°:  -9.10kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  66nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  103nM ΔG°:  -8.85kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  103nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  103nM ΔG°:  -10.0kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  867nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  867nM ΔG°:  -8.68kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM163946(US9062078, 77 | US9637496, 77 | US9695183, 77)
Affinity DataKi:  867nM ΔG°:  -8.68kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F...More data for this Ligand-Target Pair
In DepthDetails US Patent