BDBM164794 US10604504, Example 1::US11623921, Example 1::US9688629, 1::US9802915, Example 1::US9920031, Example 1

SMILES Cc1c[nH]c2c(ccc(-c3cccc(NC(=O)C=C)c3C)c12)C(N)=O

InChI Key InChIKey=XJSYGWOSHPTFRV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 164794   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human full-length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system using fluorescence-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 1.20nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2023
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 1.20nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 1.20nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 1.20nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 1.20nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM164794(US9688629, 1 | US9802915, Example 1 | US9920031, E...)
Affinity DataIC50: 15nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in intracellular calcium level incubated for 1 hr measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed