BDBM164948 US10166239, Ex. 3-43::US11406644, Example 3-43::US9067914, Ex. 3-43

SMILES COc1ccc(cn1)C(Oc1ccc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)cc1OC)C1CC1

InChI Key InChIKey=YCMJHUJBSMXAEJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 164948   

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 58nMAssay Description:In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 51nMAssay Description:In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 794nMAssay Description:In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 58nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 51nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 794nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 58nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 51nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 794nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 58nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 51nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

LigandPNGBDBM164948(US9067914, Ex. 3-43 | US10166239, Ex. 3-43 | US114...)
Affinity DataIC50: 794nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent