BDBM164969 US10166239, Ex. 3-58-3::US11406644, Example 3-58-3::US9067914, Ex. 3-58-3

SMILES COc1ccc(cn1)C(C)Oc1ccc(Cn2cnc3cc(cnc23)-c2ccnc(F)c2)cc1OC

InChI Key InChIKey=CUPFAGGKFONJEC-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 164969   

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 215nMAssay Description:In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 68nMAssay Description:In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 102nMAssay Description:In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 215nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 68nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 102nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 215nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 68nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

LigandPNGBDBM164969(US9067914, Ex. 3-58-3 | US10166239, Ex. 3-58-3 | U...)
Affinity DataIC50: 102nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent