BDBM164972 US9067917, 5::US9682971, 5

SMILES CC(C)(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(OC(F)(F)F)c1)C(O)=O

InChI Key InChIKey=IYPFFFMAECCKFQ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 164972   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM164972(US9067917, 5 | US9682971, 5)
Affinity DataIC50: 380nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction of LTB4 formation preincubated with enzyme for 15 mins followed by calcium ionophore A2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM164972(US9067917, 5 | US9682971, 5)
Affinity DataKi:  450nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2018
Entry Details
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM164972(US9067917, 5 | US9682971, 5)
Affinity DataKi:  450nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM164972(US9067917, 5 | US9682971, 5)
Affinity DataKi:  450nMAssay Description:Inhibition of N-terminal His6-tagged human FLAP expressed in Sf9 insect cells assessed as inhibition constant incubated for 2 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed