BDBM16525 2-arylpyridazin-3-one, 31::2-{3-[(2-chloro-4-fluorophenyl)[1-(2-chlorophenyl)-6-oxo-1,6-dihydropyridazin-3-yl]amino]propyl}-2,3-dihydro-1H-isoindole-1,3-dione

SMILES Fc1ccc(N(CCCN2C(=O)c3ccccc3C2=O)c2ccc(=O)n(n2)-c2ccccc2Cl)c(Cl)c1

InChI Key InChIKey=QGJNGXXVCVFADC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16525   

TargetMitogen-activated protein kinase 11(Mus musculus (mouse))
Merck Research Laboratories

LigandPNGBDBM16525(2-arylpyridazin-3-one, 31 | 2-{3-[(2-chloro-4-fluo...)
Affinity DataIC50:  20nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

LigandPNGBDBM16525(2-arylpyridazin-3-one, 31 | 2-{3-[(2-chloro-4-fluo...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair