BDBM16731 Naphthyl Compound, 5b::ethyl 2-{4-[2-(naphthalene-1-amido)-4-phenylphenyl]piperazin-1-yl}acetate

SMILES CCOC(=O)CN1CCN(CC1)c1ccc(cc1NC(=O)c1cccc2ccccc12)-c1ccccc1

InChI Key InChIKey=VELNTZUBONHZJA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16731   

TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16731(Naphthyl Compound, 5b | ethyl 2-{4-[2-(naphthalene...)
Affinity DataIC50:  90nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16731(Naphthyl Compound, 5b | ethyl 2-{4-[2-(naphthalene...)
Affinity DataIC50:  90nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed