BDBM17016 (3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::CHEMBL85403::Indolinone based inhibitor, 1a

SMILES Cc1cccc2NC(=O)\C(=C/c3ccc[nH]3)c12

InChI Key InChIKey=IUMPCHAHZBLTKY-FLIBITNWSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 17016   

Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50:  510nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50:  3.09E+4nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50:  3.10E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM17016((3Z)-4-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed