BDBM171272 1-(2-((1R,3S,5R)-3-(((R)-1-(3-Chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (6)::US9085555, 702
SMILES C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12)c1cccc(Cl)c1F
InChI Key InChIKey=YAALCKJNOOFODD-SKNMWMDOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 171272
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:Briefly, recombinant human or murine FD catalytic domain (10 nM concentration) were incubated with compound at various concentrations for 1 h at room...More data for this Ligand-Target Pair
Affinity DataIC50: 860nMpH: 7.5 T: 2°CAssay Description:Briefly, recombinant human or murine FD catalytic domain (10 nM concentration) were incubated with compound at various concentrations for 1 h at room...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.4 T: 2°CAssay Description:Recombinant human FD (10 nM concentration) was incubated with compound
at various concentrations for 1 h at room temperature in 0.1 M PBS (pH
7.4) ...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human complement factor D using Z-L-Lys-SBzl hydrochloride as substrate preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 5.6 T: 2°CAssay Description:Recombinant human KLK7 (5 nM concentration) was pre-incubated with inhibitor at various concentrations for 1 h at room temperature in 50 mM sodium ci...More data for this Ligand-Target Pair
Affinity DataKd: 6.03nMpH: 7.4 T: 2°CAssay Description:Single cycle kinetics (SCK): five increasing concentrations were injected successively without allowing for the dissociation of the protein-ligand co...More data for this Ligand-Target Pair
Affinity DataKd: 6.55nMpH: 7.4 T: 2°CAssay Description:Standard kinetics: an independent association-dissociation cycle was run for each concentration by injecting compound solution and waiting for dissoc...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Human CVF-Bb complex (3 nM concentration) was incubated with compound at
various concentrations for 1 h at room temperature in PBS at pH 7.4,
conta...More data for this Ligand-Target Pair