BDBM171414 US9085576, 142::US9085576, 48::US9611261, Example 48

SMILES NC1=N[C@@](CF)([C@H]2C[C@H]2O1)c1cc(NC(=O)c2ccc(Cl)cn2)cc(F)c1F

InChI Key InChIKey=DDSXLJNBGIUGBD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 171414   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM171414(US9085576, 142 | US9085576, 48 | US9611261, Exampl...)
Affinity DataIC50: 43.9nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM171414(US9085576, 142 | US9085576, 48 | US9611261, Exampl...)
Affinity DataIC50: 1.54E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM171414(US9085576, 142 | US9085576, 48 | US9611261, Exampl...)
Affinity DataIC50: 43.9nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM171414(US9085576, 142 | US9085576, 48 | US9611261, Exampl...)
Affinity DataIC50: 97.1nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM171414(US9085576, 142 | US9085576, 48 | US9611261, Exampl...)
Affinity DataIC50: 1.54E+5nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM171414(US9085576, 142 | US9085576, 48 | US9611261, Exampl...)
Affinity DataIC50: 2.29E+5nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
US Patent