BDBM171711 US9085576, 341

SMILES NC1=C[C@](CF)([C@@H]2C[C@@H]2O1)c1cc(Nc2nccc3cc(Cl)cnc23)cc(F)c1F

InChI Key InChIKey=DCYNKTBUADQJCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 171711   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM171711(US9085576, 341)
Affinity DataIC50: 3.41E+3nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM171711(US9085576, 341)
Affinity DataIC50: 2.89E+6nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
US Patent