BDBM171819 US9085576, 320

SMILES C[C@]1([C@H]2C[C@H]2OC(=N1)N)c3cc(ccc3F)NC(=O)c4cnc(cn4)OC

InChI Key InChIKey=LUOFRFUNXXGHFC-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 171819   

TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM171819(US9085576, 320)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM171819(US9085576, 320)
Affinity DataIC50: 81nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)