BDBM172453 US20240307363, Compound 8::US9090625, 5::US9260450, 5::US9938289, 5
SMILES Cc1cccc(n1)-n1nc2CCCc2c1-c1cc2cnccc2s1
InChI Key InChIKey=JQKNNVYRFRWQST-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 172453
Affinity DataIC50: 12.9nMAssay Description:Pharmacol 2002, 62 58-62) The compounds named in the specified Examples were tested as follows for inhibition of ALK-5 autophosphorylation activity a...More data for this Ligand-Target Pair
Affinity DataIC50: 12.9nMAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 μL Assay Buffer is added to reach well. Add 10 μL of Cold ATP mix in Assay B...More data for this Ligand-Target Pair
Affinity DataIC50: 12.9nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
Affinity DataIC50: 21.8nMAssay Description:ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...More data for this Ligand-Target Pair
Affinity DataIC50: 30.8nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair