BDBM173252 US10323032, Example 4::US9096596, 4::US9604982, Example 4

SMILES Clc1cccc(C(=O)N2CCc3c(C2)ncnc3-c2cn[nH]c2)c1Cl

InChI Key InChIKey=DFQAPFAWLCCLSM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 173252   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 388nMAssay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 388nMAssay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 388nMAssay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 388nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high gluc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 1.25E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high gluc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 1.25E+4nMAssay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 1.25E+4nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 173252BDBM173252(US9096596, 4 | US9604982, Example 4 | US10323032, ...)
Affinity DataIC50: 1.25E+4nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent