BDBM174774 US10053462, 5::US9102686, 5::US9540388, 5

SMILES Fc1ccc(cc1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F

InChI Key InChIKey=NRHCTGLCTSKNEY-UHFFFAOYSA-N

Data  5 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 174774   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataKi:  12.6nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataKi:  12.6nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataKi:  13nM IC50: 15nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataKi:  13nM IC50: 63nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataKi:  13nM IC50: 133nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataIC50: 14.7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataIC50: 14.7nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataIC50: 63.4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 174774BDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataIC50: 63.4nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent