BDBM176925 US10307413, Compound 75::US10391089, Compound 75::US10980794, Cmpd No 75::US9675614, 75

SMILES OC(CNC(=O)c1cncc(NC2CCOCC2)n1)CN1CCc2ccccc2C1

InChI Key InChIKey=NIOTUILBQXZBQQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176925   

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 176925BDBM176925(US9675614, 75 | US10307413, Compound 75 | US103910...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 176925BDBM176925(US9675614, 75 | US10307413, Compound 75 | US103910...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 176925BDBM176925(US9675614, 75 | US10307413, Compound 75 | US103910...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 176925BDBM176925(US9675614, 75 | US10307413, Compound 75 | US103910...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2018
Entry Details
US Patent