BDBM17733 2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-N-(3-phenylphenyl)carbamate::2-aminopyrimidine carbamate, 32

SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N(C(=O)Oc2c(C)cccc2C)c2cccc(c2)-c2ccccc2)cc1

InChI Key InChIKey=GPYPLTYWZZWNHS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17733   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM17733(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50:  49nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17733(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50:  1.90E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

LigandPNGBDBM17733(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50:  8.00E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

LigandPNGBDBM17733(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50:  500nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed