BDBM18069 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine::CHEMBL22::TMP::Trimethoprim::Trimethoprim (TMP)::US10870625, Compound TMP
SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI Key InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 18069
Affinity DataKi: 3.09E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
Affinity DataKi: 3.09E+3nMpH: 7.2Assay Description:Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.05E+5nMpH: 7.2Assay Description:Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
Affinity DataKi: 1.05E+5nMpH: 7.2Assay Description:Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition against dihydrofolate reductase enzyme of Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition against dihydrofolate reductase enzyme of rat liverMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium berghei (strain Anka))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium bergheiMore data for this Ligand-Target Pair