BDBM18125 (2S)-2-aminobutanedioic acid::Aspartate::CHEMBL274323::L-Aspartate::L-Aspartic acid, 2::L-[14C]aspartate

SMILES N[C@@H](CC(O)=O)C(O)=O

InChI Key InChIKey=CKLJMWTZIZZHCS-REOHCLBHSA-N

Data  5 KI  8 IC50  1 Kd  3 EC50

PDB links: 37 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 18125   

LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi:  1.40E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi:  8.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetN(4)-(beta-N-acetylglucosaminyl)-L-asparaginase(Homo sapiens (Human))
University Of North Carolina

LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKi:  6.00E+5nM ΔG°:  -4.57kcal/molepH: 5.8 T: 2°CAssay Description:Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  9.33E+3nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 4(Rattus norvegicus)
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 4(Rattus norvegicus)
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate transporter homolog(Pyrococcus horikoshii (strain ATCC 700860 / DSM 12...)
Columbia University

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataKd:  1nMAssay Description:Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter L130W mutant fluorescence-based assay in presence of NaClMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu1-alpha receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM18125((2S)-2-aminobutanedioic acid | Aspartate | CHEMBL2...)
Affinity DataIC50:  3.31E+4nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed