BDBM182040 US9145391, 1-6::US9145391, 1-7::US9145391, 1-9

SMILES COC(=O)C1CCC(O)(CC1(C)C)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1

InChI Key InChIKey=JFQHUCCGXQFLTP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 182040   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM182040(US9145391, 1-7 | US9145391, 1-9 | US9145391, 1-6)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM182040(US9145391, 1-7 | US9145391, 1-9 | US9145391, 1-6)
Affinity DataIC50: 245nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM182040(US9145391, 1-7 | US9145391, 1-9 | US9145391, 1-6)
Affinity DataIC50: 405nMpH: 7.5 T: 2°CAssay Description:A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent