BDBM187113 US9670157, 127 1-(2-Methyl-quinolin-6-ylmethyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid 4-aminomethyl-2,6-dimethyl-benzylamide::US9834513, 127

SMILES Cc1ccc2cc(Cn3ncc(C(=O)NCc4c(C)cc(CN)cc4C)c3C(F)(F)F)ccc2n1

InChI Key InChIKey=VJTIBJURDVORHW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 187113   

TargetPlasma kallikrein(Human)
Kalvista Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 187113BDBM187113(US9670157, 127 1-(2-Methyl-quinolin-6-ylmethyl)-5-...)
Affinity DataIC50: 731nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 187113BDBM187113(US9670157, 127 1-(2-Methyl-quinolin-6-ylmethyl)-5-...)
Affinity DataIC50: 731nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 187113BDBM187113(US9670157, 127 1-(2-Methyl-quinolin-6-ylmethyl)-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 187113BDBM187113(US9670157, 127 1-(2-Methyl-quinolin-6-ylmethyl)-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 187113BDBM187113(US9670157, 127 1-(2-Methyl-quinolin-6-ylmethyl)-5-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent