BDBM188497 2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl)-2-(tert-butoxy)acetic acid::ALLINI-2

SMILES Cc1nc2ccc(Br)cc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(O)=O

InChI Key InChIKey=UXIVWMINNPGARX-UHFFFAOYSA-N

Data  8 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 188497   

TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  180nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  2.00E+5nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  170nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [A1275T](Human immunodeficiency virus 1 (Virus))
The Ohio State University

LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  890nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataEC50:  146nMAssay Description:Induction of HIV1 His/FLAG-tagged integrase hyper-multimerization expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  150nMAssay Description:Inhibition of LEDGF/p75-dependant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  136nMAssay Description:Inhibition of biotinylated-TAR-RNA binding to HIV1 His6-tagged integrase expressed in Escherichia coli BL21(DE3) preincubated for 2 hrs followed by R...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  150nMAssay Description:Inhibition of LEDGF/p75 binding to HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataIC50:  120nMAssay Description:Inhibition of LEDGF/p75-independant HIV1 His/FLAG-tagged integrase expressed in Escherichia coli BL21(DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM188497(2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...)
Affinity DataEC50:  70nMAssay Description:Inhibition of N-terminal His/flag-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) incubated for 2.5 hrs by HTRF assayMore data for this Ligand-Target Pair