BDBM190177 EPZ004710::US10273223, Compound B-132::US9175331, 2::US9637472, Compound B-132

SMILES CC(C)n1ncc2c(cc(C)nc12)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=RENWHTRYJDRPJJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 190177   

LigandPNGBDBM190177(US9175331, 2 | EPZ004710 | US9637472, Compound B-1...)
Affinity DataIC50: 319nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

LigandPNGBDBM190177(US9175331, 2 | EPZ004710 | US9637472, Compound B-1...)
Affinity DataIC50: 538nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandPNGBDBM190177(US9175331, 2 | EPZ004710 | US9637472, Compound B-1...)
Affinity DataIC50: 2.98E+3nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

LigandPNGBDBM190177(US9175331, 2 | EPZ004710 | US9637472, Compound B-1...)
Affinity DataIC50: 3.79E+3nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandPNGBDBM190177(US9175331, 2 | EPZ004710 | US9637472, Compound B-1...)
Affinity DataIC50: 6.50E+3nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandPNGBDBM190177(US9175331, 2 | EPZ004710 | US9637472, Compound B-1...)
Affinity DataIC50: 6.50E+3nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent