BDBM190233 US9174999, Table 1, Compound 1
SMILES NC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]22NC(=N)N[C@@H]12
InChI Key InChIKey=RPQXVSUAYFXFJA-HGRQIUPRSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 190233
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 2.40nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 702nMAssay Description:Inhibition of human Nav1.7 expressed in CHO cells at -100 mV holding potential by electrophysiology whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [M1240A](Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 90nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 702nMAssay Description:Inhibition of human Nav1.7 expressed in CHO cells at holding potential of -100 mV by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 11 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.9 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics
Curated by ChEMBL
Siteone Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [I757A](Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 30nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair