BDBM190736 US9181236, 38

SMILES C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(ccc1F)-c1cncc(c1)C#N

InChI Key InChIKey=ZMEFTVWOMQBUQF-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 190736   

TargetBeta-secretase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190736(US9181236, 38)
Affinity DataKi: <100nM ΔG°: <-9.70kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2016
Entry Details
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TargetBeta-secretase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190736(US9181236, 38)
Affinity DataKi:  939nM ΔG°:  -8.35kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2016
Entry Details
Go to US Patent