BDBM19138 tert-butyl N-[(1S)-1-(adamantan-1-ylcarbamoyl)-6-sulfanylhexyl]carbamate::thiolate analogue, 20a

SMILES CC(C)(C)OC(=O)N[C@@H](CCCCCS)C(=O)NC12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=NKBMBTJJIYPODH-XDHFQJGLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19138   

TargetHistone deacetylase 6(Mus musculus)
Nagoya City University

LigandPNGBDBM19138(tert-butyl N-[(1S)-1-(adamantan-1-ylcarbamoyl)-6-s...)
Affinity DataIC50:  82nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Nagoya City University

LigandPNGBDBM19138(tert-butyl N-[(1S)-1-(adamantan-1-ylcarbamoyl)-6-s...)
Affinity DataIC50:  4.20E+3nMAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nagoya City University

LigandPNGBDBM19138(tert-butyl N-[(1S)-1-(adamantan-1-ylcarbamoyl)-6-s...)
Affinity DataIC50:  3.80E+3nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed