BDBM192391 US9187462, II-1::US9187462, II-2

SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC(C)C(F)(F)F)nc2c1)c1cnn(C)c1

InChI Key InChIKey=ZNTSMVKYLVMTDD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 192391   

TargetMitogen-activated protein kinase 1 [8-360](Human)
Array Biopharma

US Patent
LigandPNGBDBM192391(US9187462, II-2 | US9187462, II-1)
Affinity DataIC50: 6.20nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1 [8-360](Human)
Array Biopharma

US Patent
LigandPNGBDBM192391(US9187462, II-2 | US9187462, II-1)
Affinity DataIC50: 13.6nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2016
Entry Details
Go to US Patent