BDBM193090 US9193736, 6

SMILES C(Sc1ccc2ccccc2n1)c1nc2c(ccnn2c1-c1ccc(nc1)N1CCNCC1)N1CCOCC1

InChI Key InChIKey=IETOARBBCSQTOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 193090   

LigandPNGBDBM193090(US9193736, 6)
Affinity DataIC50: 20nMAssay Description:Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6 Hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193090(US9193736, 6)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM193090(US9193736, 6)
Affinity DataIC50: 25nMpH: 7.8Assay Description:Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2016
Entry Details
US Patent