BDBM19454 4-[2-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol::Pyrazolo[1,5-a]pyrimidine, 3

SMILES Oc1ccc(cc1)-c1nn2c(cc(nc2c1-c1ccc(O)cc1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=VEKHAWLAUFKERN-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19454   

TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

LigandPNGBDBM19454(4-[2-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)pyr...)
Affinity DataKi:  26nM ΔG°:  -9.47kcal/mole EC50:  6.00E+3nMpH: 7.5 T: 2°CAssay Description:Relative binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer, and purified full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Illinois At Urbana-Champaign

LigandPNGBDBM19454(4-[2-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)pyr...)
Affinity DataKi:  48nM ΔG°:  -9.14kcal/mole EC50:  600nMpH: 7.5 T: 2°CAssay Description:Relative binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer, and purified full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed