BDBM195138 US10336717, Compound 199::US9212153, 199,Ex. 159

SMILES COC1CCC2(Cc3ccc(C=C)cc3C22N=C(N)N(C)C2=O)CC1

InChI Key InChIKey=XZORAVYRRVCQGA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 195138   

TargetBeta-secretase 1 [1-458](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195138(US9212153, 199,Ex. 159 | US10336717, Compound 199)
Affinity DataIC50: 111nMpH: 4.4Assay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195138(US9212153, 199,Ex. 159 | US10336717, Compound 199)
Affinity DataIC50: 111nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent