BDBM196906 US9212196, Derivative 2

SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O

InChI Key InChIKey=BGOFVWMHMQISHB-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 196906   

LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  24nMAssay Description:Agonist activity against rat mGlu4 K74A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 4(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  110nMAssay Description:Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  110nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
US Patent

TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  4.20E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
US Patent

TargetMetabotropic glutamate receptor 6(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  4.91E+3nMAssay Description:Agonist activity at rat mGlu4 R258A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  9.07E+3nMAssay Description:Agonist activity against rat mGlu4 R60A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  1.16E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
US Patent

TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  1.82E+4nMAssay Description:Agonist activity at rat mGlu7 Q258A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  1.85E+4nMAssay Description:Agonist activity against rat mGlu4 S160D mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  2.62E+4nMAssay Description:Agonist activity against rat mGlu4 S160A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 8(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  2.92E+4nMAssay Description:Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  2.92E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
US Patent

TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at rat mGlu7 N74A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at rat mGlu7 N74K mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  1.78E+5nMAssay Description:Agonist activity at rat mGlu7 K60A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity at rat mGlu7 K60A/S160A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMetabotropic glutamate receptor 7(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity at rat mGlu7 S160A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details