BDBM19754 benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(4-methoxyphenyl)ethyl]carbamoyl}-3-methylbutyl]carbamate::dipeptidyl nitrile, 5c

SMILES COc1ccc(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)C#N)cc1

InChI Key InChIKey=MBRJRDMYBURHPH-UNMCSNQZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19754   

TargetCathepsin K(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19754(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(4-methoxyphenyl...)
Affinity DataIC50:  63nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19754(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(4-methoxyphenyl...)
Affinity DataIC50:  700nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19754(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(4-methoxyphenyl...)
Affinity DataIC50:  1.10E+3nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed