BDBM198121 HPOB

SMILES c1ccc(cc1)N(CCO)C(=O)Cc2ccc(cc2)C(=O)NO

InChI Key InChIKey=RFAZNTABYJYOAR-UHFFFAOYSA-N

Data  1 KI  86 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 91 hits for monomerid = 198121   

TargetHistone deacetylase 6 [440-798](Zebrafish)
University of Pennsylvania

LigandPNGBDBM198121(HPOB)
Affinity DataKi:  1nM ΔG°:  -12.3kcal/mole IC50: 1.80nMT: 2°CAssay Description:The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 25nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 34nMAssay Description:Inhibition of HDAC6 (unknown origin) using Fluor de lys as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of human HDAC6 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of human HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of human HDAC6 incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 45 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of zinc-dependent recombinant human HDAC6 incubated for 30 mins in presence of substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human HDAC6 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 56nMAssay Description:Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant human HDAC6 using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 79nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 85nMAssay Description:Inhibition of N-terminal GST-tagged full length human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using ZMAL-(Z-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 121nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 121nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 316nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 842nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant HDAC4 incubated for 45 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Universite de Poitiers

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Universite de Poitiers

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human HDAC3 after 15 mins by by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human HDAC4 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Universite de Poitiers

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Universite de Poitiers

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using Fluor de lys as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using Fluor de lys as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Universite de Poitiers

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant HDAC1 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of C-terminal his/FLAG-tagged full length human recombinant HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using ZMAL-(Z-Lys(Ac)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone deacetylase 2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human HDAC8 after 15 mins by trypsin-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human recombinant HDAC8 incubated for 45 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal HDAC8 expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Northwest A&F University

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human HDAC8 using fluorescent substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant human FLAG/His-tagged HDAC1 expressed in baculovirus expression system using 7-AMC-labelled HDAC substrate measured after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM198121(HPOB)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of zinc-dependent recombinant human HDAC1 incubated for 30 mins in presence of substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
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