BDBM20080 dipeptide-derived nitrile, 1::tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carbamate

SMILES CC(C)(C)OC(=O)NCC(=O)NCC#N

InChI Key InChIKey=XPPHLZBEBMODOV-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 20080   

TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM20080(tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carba...)
Affinity DataKi: >330nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetPapain(Papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20080(tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carba...)
Affinity DataKi: >3.00E+6nM ΔG°: >-3.44kcal/molepH: 6.5 T: 2°CAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Bovine)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20080(tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carba...)
Affinity DataKi: >1.00E+6nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20080(tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carba...)
Affinity DataKi: >1.00E+6nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20080(tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carba...)
Affinity DataKi: >1.00E+6nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed