BDBM20087 dipeptide-derived nitrile, 7::tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-3-methylbutyl]carbamate

SMILES CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N

InChI Key InChIKey=OMQSGXGRANQGLE-JTQLQIEISA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 20087   

TargetCathepsin K(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  120nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  130nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Bos taurus (bovine))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  1.20E+3nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  2.00E+3nM ΔG°:  -7.77kcal/molepH: 6.5 T: 2°CAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  2.51E+3nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM20087(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Affinity DataKi:  9.40E+4nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed