BDBM20412 3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)phenyl]urea::naphthalene deriv., 1

SMILES CSc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1

InChI Key InChIKey=GYHZBYPKMNZJKG-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 20412   

LigandPNGBDBM20412(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Affinity DataEC50:  22nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20412(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM20412(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Affinity DataIC50: 7.10nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM20412(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM20412(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed