BDBM207589 US9260440, 34::US9617273, Example 34

SMILES O=C1NN=C2CCCc3c2c2c1cccc2n3CCN1CCCC1

InChI Key InChIKey=ASIFNLNMOYRKGY-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 207589   

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207589BDBM207589(US9260440, 34 | US9617273, Example 34)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207589BDBM207589(US9260440, 34 | US9617273, Example 34)
Affinity DataIC50: 11nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207589BDBM207589(US9260440, 34 | US9617273, Example 34)
Affinity DataIC50: 11nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207589BDBM207589(US9260440, 34 | US9617273, Example 34)
Affinity DataEC50:  33nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207589BDBM207589(US9260440, 34 | US9617273, Example 34)
Affinity DataIC50: 150nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207589BDBM207589(US9260440, 34 | US9617273, Example 34)
Affinity DataIC50: 150nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent