BDBM207984 3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxy-1,5-dihydro-2H-furan-2-one (2a)

SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(Cc2ccc(Cl)cc2)=C1c1c[nH]c2cc(Cl)ccc12

InChI Key

Data  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 207984   

TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM207984(3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd:  3.10E+3nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM207984(3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-...)
Affinity DataKd: <1.00E+3nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB